Dynamics of neurospecific autoimmune disorders and cognitive functions in patients with polytrauma and alcohol withdrawal syndrome complicated by alcohol delirium

Annotation. Polytrauma is considered the main cause of death among people younger 45 years. Among trauma patiens 15-20% regularly take alcohol, close to 32% patients who needed intensive therapy alcohol withdrawal syndrome (AWS), and 5-20% progressed delirium. The aim study analyze dynamics autoimmune response markers neurodestruction in blood with moderate polytrauma withdrawal, complicated by delirium assessment cognitive functions depending on method sedation. involved 80 median age was years (39-54). Patients Group 1 (n=40) were given dexmedetomidine as a sedation method, 2 diazepam used according symptom-trigger protocol. content antibodies neuron-specific enolase (NSE), myelin basic protein (MBP), total human brain antigen (THBA), S-100 calcium determined enzyme-linked immunosorbent assay days 1, 3, 7 14 after Assessment function performed (after from if present) 4 using Montreal Cognitive Scale (MoCa). Mathematical processing obtained results accordance generally accepted methods statistical analysis. critical value significance level (p) taken ?5%. Signs, distribution which differed normal, are presented form Me (median), confidence interval within first third quarters [QI - QIII]. To assess causal role various factors development lesions ?-square inclusion Yates correction odds ratio. In 24 hours manifestation AD, levels autoantibodies two groups did not differ significantly healthy volunteers. Estimation S-100B showed that group this indicator increased maximum 24.4% amounted 15.8 [14.7 17.6], while second 32.6% became 17.5 [15.3 19.7]. From 7th day, number began decrease both 15.6 [13.6 16.8] 16.3 [14.1-19.2] 14.0 [11.6 15.3] 15.2 [ 13.1 18.3], respectively, 14th day hospitalization ICU. NSE 3rd 29.8 [28.4 31.8] higher than initial 26.8%, 31.6 [29.5 -33.2], exceeds baseline 33.9% (p=0.0114 between 2). Subsequently, there onset maintaining significant difference comparison groups. Antibodies MBP up including but On 26.8 [24.4 28.8], corresponded values control group, 29.3 [27.7 31.5], more (p = 0.0017). 14, trend maintained: OBM 28.6 [27.0 30.8], it 26.2 [23.7 28.2]. Antibody THBA 3 30.8 34.5] 32.7 [30.6 36.1] (p=0.0056). they 31.5 [29.4 34.9] normalized 14. When analyzing MoCa test eliminating manifestations (4 admission ICU), points lower values: 1.3 times <0.0001), – 1.6 (p<0.0001). differences studied 0.000087). Thus, use for hypertension reduces autumnal neurodestruction, improves prognosis restoration function.